database / gh-secretagogue
IGF-1 LR3
also known as Long R3 IGF-1
Sequence
Primary structure not characterised in the public record.
An 83-residue analogue of insulin-like growth factor 1 with an Arg3 substitution and a 13-residue N-terminal extension — a protein-scale construct, not transcribed here.
Molecular data
| molecular formula | not characterised |
|---|---|
| molecular weight | not characterised |
| computed backbone mass | not characterised |
| length | not characterised |
| net charge (pH 7.4) | not characterised |
| mean hydropathy | not characterised |
| half-life | not characterised |
| delivery route | not characterised |
| PubChem CID | not characterised |
| PDB | not characterised |
| UniProt parent | P05019 |
Mechanism
IGF-1 analogue with reduced IGF-binding-protein affinity.
Reported targets: IGF1R
Experimental structure
No experimental structure deposited in the PDB. A predicted fold is not a structure, so nothing is drawn.
Parent protein
Analogue of mature IGF-1. UniProt P05019 · 195 aa
Reported effects
Each row is an outcome described in the literature indexed for this peptide.
| reported outcome | where it appears |
|---|---|
| anabolic signalling in models | Effect of recombinant porcine IGFBP-3 on IGF-I and long-R3-IGF-I-stimulated … Journal of cellular physiology 2004 |
Literature (8)
Effect of recombinant porcine IGFBP-3 on IGF-I and long-R3-IGF-I-stimulated proliferation and differentiation of L6 myogenic cells — Journal of cellular physiology 2004
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 15254966 · DOI 10.1002/jcp.20068
Effects of insulin-like growth factor-I and its analogue, long-R3-IGF-I, on intestinal absorption of 3-O-methyl-D-glucose are less pronounced than gut mucosal growth responses — Growth factors (Chur, Switzerland) 2002
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 11999215 · DOI 10.1080/08977190290022194
Production of recombinant porcine IGF-binding protein-5 and its effect on proliferation of porcine embryonic myoblast cultures in the presence and absence of IGF-I and Long-R3-IGF-I — The Journal of endocrinology 2005
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 15817840 · DOI 10.1677/joe.1.06037
Endocrine and metabolic changes in neonatal calves in response to growth hormone and long-R3-insulin-like growth factor-I administration — Biology of the neonate 1998
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 9483305 · DOI 10.1159/000013968
Enhancement of maternal lactation performance during prolonged lactation in the mouse by mouse GH and long-R3-IGF-I is linked to changes in mammary signaling and gene expression — The Journal of endocrinology 2008
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 18577570 · DOI 10.1677/joe-07-0556
The somatotropic axis in neonatal calves can be modulated by nutrition, growth hormone, and Long-R3-IGF-I — The American journal of physiology 1997
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 9252489 · DOI 10.1152/ajpendo.1997.273.1.e130
Response of isolated ruminant mammary arteries to the long R3 analogue of insulin-like growth factor I — Experimental physiology 2000
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 10825414 · DOI 10.1111/j.1469-445x.2000.01973.x
Chemical treatment of Escherichia coli. II. Direct extraction of recombinant protein from cytoplasmic inclusion bodies in intact cells — Biotechnology and bioengineering 1998
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 10099214 · DOI 10.1002/(sici)1097-0290(19980220)57:4<381::aid-bit1>3.0.co;2-i
The mechanism, illustrated
Not memed yet.
33 of the 100 indexed peptides have one. See which →
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